Canis ISSN: 2398-2942

Skin: hypoandrogenism

Synonym(s): Testosterone-responsive dermatosis

Contributor(s): Rosanna Marsella, David Scarff

Introduction

  • Rare syndrome of castrated dogs.
  • Cause: decreased androgen levels?
  • Signs: most common in dogs castrated between 6 and 9 months of age.
  • Causes bilaterally symmetrical alopecia.
  • Diagnosis: history, clinical signs, histopathology.
  • Treatment: methyltestosterone.
  • Prognosis: good.

Pathogenesis

Etiology

  • ?Decreased androgens: serum testosterone has been essentially zero in dogs that respond to replacement therapy.

Specific

  • Castration before 9 months of age.

Pathophysiology

  • ?Inadequate level of basal androgens from adrenal gland.
  • ?Defective metabolism of sex hormones in skin receptor sites.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Schmeitzel L P (1990) Sex hormone related and growth hormone related alopecias. Vet Clin North Am Small Anim Pract 20 (6), 1579-601 PubMed.
  • Schmeitzel L P & Lothrop C D (1990) Sex hormones and skin disease. Vet Med Report 2 (1), 28-41 VetMedResource.
  • Medleau L (1989) Sex hormone associated endocrine alopecias in dogs. JAAHA 25 (6), 689-94 VetMedResource.
  • Scott D W (1982) Histologic findings in the endocrine skin disorders of the dog. JAAHA 18 (1), 173-83 VetMedResource.

Other sources of information

  • Muller G Het al(eds) (1995)Small Animal Dermatology.5th edn. Philadelphia: W B Saunders. pp 627-719. (Detailed dermatology text book for in-depth reading.)
  • Ferguson E A (1993)Symmetrical alopecia in the dog.In:Manual of Small Animal Dermatology.Eds: Locke P H, Harvey R G & Mason I S. Cheltenham: British Small Animal Veterinary Association. pp 101-113. (Excellent systematic approach leading to definitive diagnosis.)
  • Griffin C E, Kwochka K W & MacDonald J M (1993)Current veterinary dermatology - the science and art of therapy.In:Handbook of Small Animal Dermatology.Eds: Morrelo, K A & Mason, I S. Oxford: Pergamon Press. pp 75-91. (Excellent problem-oriented approaches and diagnostic plans.)
  • Grant D I (1991)Skin diseases in the Dog and Cat.2nd edn. Oxford: Blackwell Sceintific Publications. pp 67-85. (Concise for quick reference.)
  • Grant D I, Herrtage M E & Thoday K L (1990)Differential diagnosis of alopecia. The adrenal glands. The thyroid gland.In:Manual of Small Animal Endocrinology.Ed: Hutchison M. Cheltenham: British Small Animal Veterinary Association. (Good differential diagnosis.)


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