Canis ISSN: 2398-2942

Skin: hypo-estrogenism

Synonym(s): Ovarian imbalance type II

Contributor(s): Rosanna Marsella, David Scarff

Introduction

  • Rare, poorly understood dermatosis.
  • Cause: caused by deficiency of sex hormones following ovariohysterectomy at an early age.
  • Signs: bilaterally symmetrical alopecia begins in the perineal and perivulvar regions; may progress along ventral trunk and neck and occasionally the pinnae.
  • Hyperpigmentation is rare.
  • Diagnosis: history, clinical signs, histopathology.
  • Treatment: estrogen or testosterone replacement.
  • Prognosis: good.

Pathogenesis

Etiology

Specific

  • Ovariohysterectomy at an early age.

Pathophysiology

  • ?Adrenal sex hormone synthesis dysfunction (adrenal glands produce enough sex hormones for normal cell function in most neutered bitches).
  • ?Sex hormone receptor deficit in the skin.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Scott D W (1990) Seasonal flank alopecia in ovariohysterectomised dogs. Cornell Vet 80 (2), 187-195 PubMed.
  • Medleau L (1989) Sex hormone-associated endocrine alopecias in dogs. JAAHA 25 (6), 689-94 VetMedResource.


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