Canis ISSN: 2398-2942

Skin: hyperestrogenism

Synonym(s): Ovarian imbalance type 1

Contributor(s): Rosanna Marsella, David Scarff

Introduction

  • Cause: rare syndrome in entire bitches. Also in dogs some testicular tumors → feminization syndrome Skin: idiopathic male feminizing syndrome.
  • Signs: bilaterally symmetrical alopecia.
  • Diagnosis: history, clinical signs, histopathology, rule out other endocrinopathies, permanently elevated serum estradiol, progesterone or testosterone.
  • Treatment: ovariohysterectomy or removal of testicular tumor and treatment of secondary complications.
  • Prognosis: excellent.

Pathogenesis

Etiology

  • Excess ovarian production of:
    • Estradiol.
    • Progesterone.
    • Testosterone.
  • Any one or a combination may be elevated - estradiol most common.

Pathophysiology

  • Cystic ovaries or functional ovarian tumors Ovary: neoplasia (rare) → excess production of sex hormones → clinical signs dependent on which hormone or combination elevated.
  • Occasionally administration of estrogens → iatrogenic hyperestrogenism.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Fiorito D A (1992) Hyperestrogenism in bitches. Comp Cont Ed Prac Vet 14 (6), 727-9 VetMedResource.
  • Spackman C J & Roth L (1988) Prostatic cyst and concurrent Sertoli cell tumor in a dog. JAVMA 192 (8), 1096-1098 PubMed.
  • Watson A D J (1985) Oestrogen-induced alopecia in a bitch. JSAP 26 (1), 17-21 VetMedResource.
  • Mattheeuws D & Comhaire F (1975) Oestradial and testosterone in male dogs with alopecia and feminization without testicular neoplasia. Br Vet J 131 (1), 65-69 PubMed.


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