ISSN 2398-2969      

Skin: bullous pemphigoid

icanis

Introduction

  • Only disease in the Pemphigoid complex recognized in veterinary medicine.
  • Cause: rare, auto-immune, vesiculobullous, ulcerative condition resulting from breakdown in dermo-epidermal adhesion.
  • Signs: pruritus, widespread lesions of skin and mucous membranes, anorexia, paronychia.
  • Diagnosis: history, clinical signs, skin biopsy, immunofluorescence.
  • Treatment: fluid therapy, shock therapy, antibacterial drug therapy.
  • Prognosis: guarded to poor.

Pathogenesis

Etiology

  • Unknown.

Predisposing factors

General
  • In some cases the pathogenesis may involve drug administration.
  • Sulfonamides, penicillins and furosemide have been associated.
  • UV light may also be a factor.

Pathophysiology

  • Auto-antibody against an antigen of the skin and mucosa at the basement membrane level → sub-epidermal vesicle formation.
  • Bullous pemphigoid auto-antibodies → bind with hemidesmosomes of epidermal basal cells and lamina lucida of the basement membrane.
  • Complement fixation and activation → attraction of neutrophils and eosinophils → release of proteolytic enzymes → disrupts dermo-epidermal adhesion → subepidermal vesicle formation.

Timecourse

  • Can occur suddenly at any age.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • White S D, Rosychuk R A, Reinke S I et al (1992) Use of tetracycline and niacinamide for treatment of autoimmune skin disease in 31 dogs. JAVMA 200 (10), 1497-1500 PubMed.
  • Carlotti D (1989) Proceedings of 1987 symposium on skin disease at Lanwade Hall, Newmarket. JSAP 30, 223-227.
  • Johnson B W & Campbell K L (1989) Dermatoses of the canine eyelid. Comp Cont Ed Pract Vet 11 (4), 385-394 VetMedResource.
  • Griffin C E (1987) Diagnosis and management of primary autoimmune skin diseases - a review. Sem Vet Med Surg 2 (3), 173-185 PubMed.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code