Canis ISSN: 2398-2942

Skin: anagen defluxion

Synonym(s): Anagen effluvium

Contributor(s): David Scarff, Susan E Shaw

Introduction

  • Rare syndrome.
  • Cause: chemotherapy or catastrophic disease → damages shaft of growing hairs.
  • Signs: characterized by widespread excessive hair shedding.
  • Diagnosis: symmetrical alopecia and other factors.
  • Treatment: none.
  • Prognosis: guarded due to underlying factors.

Pathogenesis

Etiology

  • Interference with anagen by antimitotic drugs, infectious diseases, metabolic diseases.

Predisposing factors

General
  • Catastrophic disease.
  • Chemotherapy.

Specific

  • Infectious diseases, eg causes of severe acute pyrexia.
  • Metabolic diseases with severe and acute onset.

Pathophysiology

  • Catastrophic disease or chemotherapy → interferes with anagen phase of hair growth → abnormalities of hair follicle and shaft → break easily → excessive hair loss within days of insult.

Diagnosis

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Outcomes

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Further Reading

Publications

Refereed papers

Other sources of information

  • Scott D W, Miller W H & Griffin C E (1995)Small Animal Dermatology. 5th edn. Philadelphia: W B Saunders. ISBN 0 7216 4850 9.
  • Yager J A & Wilcock B P (1994)Color Atlas and Text of Surgical Pathology of the Dog and Cat.London: Wolfe Publishing, Mosby Year Book Europe. ISBN 0 7234 1827 6.
  • Gross T L, Irkhe P J & Walder E J (1992)Veterinary Dermatopathology.St Louis: Mosby Year Book. ISBN 0 8016 5809 8.
  • FadokV A (1985)The dynamics of hair growth and development.Dermatol Rep4, 1.


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