Canis ISSN: 2398-2942

Skin: acrodermatitis

Synonym(s): Lethal acrodermatitis, LAD

Contributor(s): David Scarff, Susan E Shaw

Introduction

  • Uncommon disorder of English Bull Terrier.
  • Cause: genetic.
  • Signs: puppies born with pale coat and small (but are often white Bull Terriers).
  • Growth is slow, footpads become cracked and skin is ulcerated.
  • Systemic signs, ocular deformities.
  • Diagnosis: breed, clinical signs, histopathology.
  • Treatment: control of secondary infection.
  • Prognosis: poor - death may occur within a year.

Pathogenesis

Predisposing factors

General

  • Inherited trait (monogenic autosomal recessive inheritance).

Pathophysiology

  • Incompletely understood; dogs have defective zinc metabolism.
  • Secondary Malassezia infection important.
  • Defective zinc metabolism.
  • Malassezia infection exacerbates clinical signs.

Timecourse

  • Signs present at birth.
  • Death often by 7 months of age.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Bauer A, Jagannathan V, Hogler S et al (2018) MKLN1 splicing defects in dogs with lethal acrodermatitis. PLoS Genet 14 (3), e1007264 PubMed.
  • McEwan N A, McNeil P E, Thompson H & McCandish I A P (2000) Diagnostic features, confirmation and disease progression in 28 cases of lethal acrodermatitis of Bull Terriers. JSAP 41 (11), 501-507 PubMed.
  • Smits B et al (1991) Lethal acrodermatitis in Bull Terriers - a problem of defective zinc metabolism. Vet Dermatol 2 (2), 91-6 VetMedResource.

Other sources of information

  • Scott D W, Miller W H & Griffin C E (1995) Small Animal Dermatology. 5th edn. Philadelphia: W B Saunders. ISBN 0 7216 4850 9.
  • Yager J A & Wilcock B P (1994) Color Atlas and Text of Surgical Pathology of the Dog and Cat. London: Wolfe Publishing, Mosby Year Book Europe. ISBN 0 7234 1827 6.
  • Gross T L, Irkhe P J & Walder E J (1992)Veterinary Dermatopathology. St Louis: Mosby Year Book. ISBN 0 8016 5809 8.

Organisation(s)


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