Canis ISSN: 2398-2942

Skin: acral mutilation syndrome

Synonym(s): AMS

Contributor(s): Rosanna Marsella, David Scarff, Laurent Garosi

Introduction

  • Rare.
  • Cause: hereditary neuropathy.
  • Signs: mutilation of limb extremities.
  • Diagnosis: clinical signs, histopathology, DNA testing.
  • Treatment: nursing care of damaged areas.
  • Diagnosis: guarded - euthanasia often requested by owner.

Pathogenesis

Etiology

  • Decreased substance P in the spinal cord and brain of affected dogs may play a role and explain lack of nociception.
  • Autosomal-recessive genetic sensory neuropathy Sensory neuropathies.

Predisposing factors

General

  • Breed.

Pathophysiology

  • Inherited sensory neuropathy.
  • Autosomal recessive.
  • Poor prenatal development of spinal ganglia, dorsal roots and certain nerve cell bodies → post-natal degeneration.

Timecourse

  • Euthanasia usually requested in first year of dog's life.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Bardagi M et al (2011) Acral mutilation syndrome in a miniature pinscher. J Comp Pathol 144 (2-3), 235-238 PubMed.
  • Paradis M et al (2005) Acral mutilation and analgesia in 13 French spaniels. Vet Dermatol 16 (2), 87-93 PubMed.
  • Hewson C J, Luescher U A, Parent J M, Conlon P D & Ball R O (1998) Efficacy of clomipramine in the treatment of canine compulsive disorder. JAVMA 213 (12), 1760-1766 PubMed.
  • Cummings J F, DeLahunta A, Simpson S T & McDonald J M (1984) Reduced substance P-like immunoreactivity in hereditary sensory neuropathy in pointer dogs. Acta Neuropathol 63 (1), 33-40 PubMed.
  • Cummings J F, DeLahunta A, Braund K G & Mitchell W J Jr (1983) Hereditary sensory neuropathy. Nociceptive loss and acral mutilation in pointer dogs - canine hereditary sensory neuropathy. Am J Pathol 112 (1), 136-138 PubMed.
  • Cummings J F, deLahunta A, Winn S S (1981) Acral mutilation and nociceptive loss in English Pointer dogs. A canine sensory neuropathy. Acta Neuropathologica 53 (2), 119-27 PubMed.


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