Canis ISSN: 2398-2942

Sensory neuropathy: Border Collie

Contributor(s): Laurent Garosi, Simon Platt

Introduction

  • Cause: hereditary disease, autosomal recessive trait.
  • Signs: knuckling of the feet, self-mutilation and progressive ataxia without paresis from 2 to 7 months of age.
  • Diagnosis: DNA testing for sensory neuropathy.
  • Treatment: none.
  • Prognosis: grave with euthanasia usually required on welfare grounds before two years of age.

Pathogenesis

Etiology

  • Genetic disease.
  • DNA mutation.
  • Autosomal recessive mode of inheritance.

Pathophysiology

  • Progressive axonopathy.

Timecourse

  • Progressive deterioration over a year to 18 months.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Harkin K R, Cash W C, Shelton G D (2005) Sensory and motor neuropathy in a Border Collie. J Am Vet Med Assoc 227 (8), 1263-1265 PubMed.
  • Vermeersch K, Van Ham L, Braund K G et al (2005) Sensory neuropathy in two Border Collie puppies. J Small Anim Pract 46 (6), 295-299 PubMed.
  • Wheeler S J (1987) Sensory neuropathy in a Border Collie puppy. J Small Anim Pract 28 (4), 281-289 VetMedResource.

Other sources of information


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