Canis ISSN: 2398-2942

Progressive axonopathy of the Boxer

Synonym(s): Sensory neuropathy of the Boxer

Contributor(s): Kyle Braund

Introduction

  • Rare in the UK, not yet recognized in US (as of 1999).
  • Seen from 1 month of age.
  • Condition is inherited as an autosomal recessive trait.
  • Signs: progressive deterioration from patellar hyporeflexia at 1 month to ataxia by 3 months.
  • Most remain able to walk and may be acceptable pets.
  • Diagnosis: EMG and nerve biopsy.
  • Treatment: none.
  • Prognosis: guarded.

Pathogenesis

Etiology

  • Inherited as an autosomal-recessive neuropathy.

Predisposing factors

General
  • Presently unknown.

Specific

  • Presently unknown.

Pathophysiology

  • It has been hypothesied that failure of slow axonal transport may occur in roots, leading to axonal swellings and secondary hypoplasia of more distal, larger-diameter fibers.

Timecourse

  • Affected animals progressively deteriorate but most remain able to walk and may be satisfactory as pets.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Nygren C (1992) Progressive axonopathy in a Boxer in Sweden [Swedish]. Svensk Vet 44 (5), 222-233 VetMedResource.
  • Fanuel-Barret D et al (1989) Progressive axonopathy of the Boxer - case report [French]. Point Vet 20 (118), 893-896 VetMedResource.
  • Griffiths I R et al (1989) Progressive axonopathy - an inherited neuropathy of Boxer dogs. An immunocytochemical study of the axonal cytoskeleton. Neuropathol Applied Neurobiol 15 (1), 63-74 PubMed.
  • Griffiths I R (1985) Progressive axonopathy - an inherited neuropathy of Boxer dogs - 1. Further studies of the clinical and electrophysiological features. JSAP 26 (7), 381-392 VetMedResource.


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