ISSN 2398-2969      

Nutritional secondary hyperparathyroidism

icanis
Contributor(s):

Penney Barber


Introduction

  • Bone disorder caused by excess parathyroid hormone (PTH) usually the result of poor nutrition.
  • Cause: diet with excess phosphorus or low calcium.
  • Signs: bone pain, stiffness, neurological signs.
  • Diagnosis: history, laboratory data, radiography.
  • Treatment: strict rest, dietary modification.
  • Prognosis: good if treated early.

Pathogenesis

Etiology

  • Feeding diet with inappropriate calcium:phosphorus ratio (should be 1.2:1).
  • Usually seen in animals fed on pure meat diet.

Pathophysiology

  • Excess PTH secretion due to inadequate dietary calcium → demineralization of bones → clinical signs.
  • Hypocalcemia (ionized calcium) as a result of inadequate intake or excess phosphate → increased PTH secretion.
  • Inability to compensate by increased dietary uptake of calcium → skeletal demineralization → osteopenia.
  • Weakness of bones may → pathological fractures → vertebral collapse and neurological signs in some cases.

Timecourse

  • Months.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Tomsa K, Glaus T, Hauser B, Fluckiger M, Arnold P, Wess G & Reusch C (2000) Nutritional secondary hyperparathyroidism in six cats. JSAP 40 (11), 533-539 PubMed.
  • Krook L, Lutwak I L, Henrikson P, Kallfelz F, Hirsch C, Romanus B, Belnager L F, Marier J F & Sheffy B E (1971) Reversibility of nutritional osteoporosis: physicochemical data on bones from an experimental study in dogs​. J Nutr 101 (2), 233-246 PubMed.

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