Canis ISSN: 2398-2942

Naproxen poisoning

Introduction

  • Non-steroidal anti-inflammatory agent (NSAID).
  • Poorly tolerated by dog.
  • Signs: gastrointestinal ulceration, blood dyscrasias.
  • Diagnosis: history, clinical signs.
  • Treatment: symptomatic.
  • Prognosis: good.
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Pathogenesis

Pathophysiology

  • Exact mode of action unknown, not mediated through the pituitary axis.
  • Along with most other NSAIDs, produces gastrointestinal damage.
  • Lesions vary from erythema, hemorrhage and erosion to ulceration and peritonitis.
  • Degree of gastrointestinal intolerance depends on the dose-level and the duration of drug administration.
  • The dog has a relatively low tolerance for the drug.
  • Gastrointestinal lesions have been seen following both parenteral and oral administration.
  • Inhibits prostaglandin cyclo-oxygenase activity, which results in a prostaglandin deficiency at the tissue level.
  • Ten times more potent than aspirin.
  • Half-life of 74 hours.
  • Naproxen may induce nephritis. Glomerular nephritis, interstitial nephritis and nephrotic syndrome have been reported in humans following use of naproxen.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Dye T L (1997) Naproxen toxicosis in a puppy. Vet Hum Toxicol 39 (3), 157-159 PubMed.
  • Gilmour M A & Walshaw R (1987) Naproxen-induced toxicosis in a dog. JAVMA 191 (11), 1431-1432 PubMed.

Other sources of information

  • MIMS Annual, MIMS Australia, ISSN 0725-4709.

Organisation(s)


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