Canis ISSN: 2398-2942

Mouth: squamous cell carcinoma (gingival)

Synonym(s): SCC

Introduction

  • Common malignant oral tumor.
  • Signs: gingival form usually presents as friable, hemorrhagic mass or erosive plaque.
  • Diagnosis: radiography essential to define tumor margin, biopsy provides definitive diagnosis.
  • Treatment: wide local excision by mandibulectomy/maxillectomy.
  • Prognosis: low metastatic rate means that early treatment can cure.
  • If inoperable, radiotherapy can give reasonable remission: 50% controlled at 1 year.

Pathogenesis

Pathophysiology

  • Irregular proliferative or ulcerative epithelial lesions at any site in upper or lower dental arcade → destruction of periodontal tissues and loosening teeth → bone invasion (70-77% of cases) → regional lymph node metastases (5-10% of cases) → distant metastases (3-36% of cases).

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Bregazzi V S et al (2001) Response of feline oral squamous cell carcinoma to palliative radiation therapy. Vet Rad Ultra 42 (1), 77-79 PubMed.
  • Schmidt B R, Glickman N W, DeNichola D B et al (2001) Evaluation of prioxicam for the treatment of oral squamous cell carcinoma in dogs. JAVMA 218 (11), 1783-1786 PubMed.
  • Frew D G & Dobson J M (1992) Radiological assessment of 50 cases of incisive or maxillary neoplasia in the dog. JSAP 33 (1), 11-18 VetMedResource.
  • White R A S (1991) Mandibulectomy and maxillectomy in the dog: long term survival in 100 cases. JSAP 32 (2), 69-74 VetMedResource.
  • Dobson J M & White R A S (1990) Oral tumours in dogs and cats. In Practice 12 (4), 135-146 VetMedResource.
  • White R A S, Gorman N T, Watkins S B & Brearley M J (1985) The surgical management of bone-involved oral tumours in the dog. JSAP 26 (12), 693-708 VetMedResource.

Other sources of information

  • Withrow S J & MacEwen E G (1996)Small Animal Clinical Oncology.2nd edition. Philadelphia: W B Saunders. ISBN 0-7216-5592-0 (Up-to-date reference on all aspects of small animal clinical oncology).
  • White R A S (1990) In:The Manual of Small Animal Dentistry, pp 101-112.Cheltenham: BSAVA. (Affordable source, very readable.)


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