Canis ISSN: 2398-2942

Malignant histiocytosis

Contributor(s): Laura Garrett, Susan North, Douglas J Weiss

Introduction

Pathogenesis

Etiology

Pathophysiology

  • Aggressive disseminated neoplastic condition.
  • Atypical histiocytes proliferate.
  • Histiocytes frequently phagocytose hemic cells.
  • Frequently results in anemia Anemia: overview or pancytopenia.
  • Malignant histiocytes proliferate in bone marrow, lungs, spleen, liver or lymph nodes.
  • Rapid proliferation of malignant cells in multiple organs results in rapid progression of signs.
  • Phagocytosis of hemic cells by malignant cells results in cytopenias of the peripheral blood.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Nielsen L, Andreasen S N, Andersen S D & Kristensen A T (2010) Malignant histiocytosis and other causes of death in Bernese mountain dogs in Denmark. Vet Rec 166 (7), 199-202 PubMed.
  • Weiss D J (2002) Flow cytometric evaluation of hemphagocytic disorders in canine. Vet Clin Pathol 31 (1), 36-41 PubMed.
  • Visonneau S et al (1997) Successful treatment of canine malignant histiocytosis with the human major histocompatibility complex nonrestricted cytoxic T-Cell Line TALL-104. Clin Cancer Research 3 (10), 1789-1797 PubMed.
  • Ramsey I K (1996) Malignant histiocytosis in three Bernese mountain dogs. Vet Rec 138 (18), 440-444 PubMed.
  • Hayden D W et al (1993) Disseminated malignant histiocytosis in a golden retriever - clinicopathologic, ultrastructural, and immunohistochemical findings. Vet Pathol 30 (3), 256-264 PubMed.
  • Moore P F & Rosin A (1986) Malignant histiocytosis of Bernese mountain dogs. Vet Pathol 23 (1), 1-10 PubMed.
  • Wellman M L, Davenport D J, Morton D et al (1985) Malignant histiocytosis in four dogs. J Am Vet Med Assoc 187 (9), 919-921 PubMed.

Other sources of information

  • DeHeer H & Grindem C B (2000)Histiocytic Disorders.In: Schalm's Veterinary Hematology. 5th Ed Lippincott Williams & Wilkins. pp696-705.
  • Withrow S J & MacEwen E G (1996)Small Animal Clinical Oncology.Philadelphia: W B Saunders. ISBN: 0-7216-7755-X.


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