ISSN 2398-2969      

Malignant histiocytosis

icanis

Introduction

Pathogenesis

Etiology

Pathophysiology

  • Aggressive disseminated neoplastic condition.
  • Atypical histiocytes proliferate.
  • Histiocytes frequently phagocytose hemic cells.
  • Frequently results in anemia Anemia: overview or pancytopenia.
  • Malignant histiocytes proliferate in bone marrow, lungs, spleen, liver or lymph nodes.
  • Rapid proliferation of malignant cells in multiple organs results in rapid progression of signs.
  • Phagocytosis of hemic cells by malignant cells results in cytopenias of the peripheral blood.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Nielsen L, Andreasen S N, Andersen S D & Kristensen A T (2010) Malignant histiocytosis and other causes of death in Bernese mountain dogs in Denmark. Vet Rec 166 (7), 199-202 PubMed.
  • Weiss D J (2002) Flow cytometric evaluation of hemphagocytic disorders in canine. Vet Clin Pathol 31 (1), 36-41 PubMed.
  • Visonneau S et al (1997) Successful treatment of canine malignant histiocytosis with the human major histocompatibility complex nonrestricted cytoxic T-Cell Line TALL-104. Clin Cancer Research 3 (10), 1789-1797 PubMed.
  • Ramsey I K (1996) Malignant histiocytosis in three Bernese mountain dogs. Vet Rec 138 (18), 440-444 PubMed.
  • Hayden D W et al (1993) Disseminated malignant histiocytosis in a golden retriever - clinicopathologic, ultrastructural, and immunohistochemical findings. Vet Pathol 30 (3), 256-264 PubMed.
  • Moore P F & Rosin A (1986) Malignant histiocytosis of Bernese mountain dogs. Vet Pathol 23 (1), 1-10 PubMed.
  • Wellman M L, Davenport D J, Morton D et al (1985) Malignant histiocytosis in four dogs. J Am Vet Med Assoc 187 (9), 919-921 PubMed.

Other sources of information

  • DeHeer H & Grindem C B (2000)Histiocytic Disorders.In: Schalm's Veterinary Hematology. 5th Ed Lippincott Williams & Wilkins. pp696-705.
  • Withrow S J & MacEwen E G (1996)Small Animal Clinical Oncology.Philadelphia: W B Saunders. ISBN: 0-7216-7755-X.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code