Canis ISSN: 2398-2942

Lung: pulmonary infiltration with eosinophilia

Synonym(s): PIE

Contributor(s): Lynelle Johnson

Introduction

  • Cause: infiltration of lung parenchyma and bronchi with eosinophils; etiology unknown but probably allergic.
  • Signs: cough (non-responsive to antibiotics), dyspnea.
  • Diagnosis: pulmonary cytology.
  • Treatment: corticosteroids.
  • Prognosis: generally good (but relapses common).

Pathogenesis

Etiology

  • Majority idiopathic.
  • Possibly immune-mediated with various allergens implicated:
    • Ascarids.
    • Dirofilariasis.
    • Dietary allergens.
    • Fungal.
    • Bacterial.
    • Inhaled allergens.
    • Neoplasia.
    • Drug exposure.

Pathophysiology

  • A syndrome with eosinophilic infiltration of interstitial tissue and increased bronchial secretions.
  • Syndrome - not a single disease.
  • All 4 hypersensitivity reactions may be involved:
    • Antigen - lg E.
    • Antibody dependent cytotoxicity.
    • Antigen - antibody complex formation.
    • Delayed type hypersensitivity.
  • Various mechanisms postulated.

Timecourse

  • Weeks to months.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Brownlie S E (1990) A retrospective study of diagnosis in 109 cases of canine lower respiratory disease. JSAP 31 (8), 371-376 VetMedResource.


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