Canis ISSN: 2398-2942

Lung: eosinophilic bronchopneumopathy

Synonym(s): EBP, pulmonary filtrates with eosinophils (PIE), eosinophilic pneumonia

Contributor(s): Lynelle Johnson, Rachel Blake

Introduction

  • Cause: infiltration of lung parenchyma and bronchi with eosinophils; etiology unknown but probably hypersensitivity.
  • Signs: cough (non-responsive to antibiotics), dyspnea.
  • Diagnosis: pulmonary cytology, rule out other causes.
  • Treatment: corticosteroids.
  • Prognosis: generally good (but relapses common).

Pathogenesis

Etiology

Pathophysiology

  • A syndrome with eosinophilic infiltration of pulmonary interstitial tissue and bronchial mucosa.
  • Various mechanisms postulated.
  • Increased CD4+ cells and decreased CD8+ cells in BAL suggests a dominant Th2 hypersensitivity response.
  • Upregulation of collagenolysis and proteolysis → lower airway and parenchymal destruction and remodeling, epithelial sloughing.

Timecourse

  • Weeks to months.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Johnson L R et al (2019) Eosinophilic bronchitis, eosinophilic granuloma and eosinophilic bronchopneumopathy in 75 dogs (2006-2016). JVIM 33(5), 2217-2226 PubMed.
  • Mesquita L et al (2014) Computed tomography findings in 15 dogs with eosinophilic bronchopneumopathy. Vet Radiol Ultrasound 56(1), 33-39 PubMed.
  • Clercx C & Peeters D (2007) Canine Eosinophilic Bronchopneumopathy, Vet Clin NorthAm Small Anim Pract 37(5) 917-935 PubMed.
  • Brownlie S E (1990) A retrospective study of diagnosis in 109 cases of canine lower respiratory disease. JSAP 31 (8), 371-376 VetMedResource.


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