Canis ISSN: 2398-2942

Liver: steroid hepatopathy

Contributor(s): Nick Bexfield

Introduction

  • Cause: exogenous glucocorticoids, hyperadrenocorticism.
  • Signs: asymptomatic, elevation in liver enzymes or very occasionally hepatic failure.
  • Diagnosis: history of glucocorticoid use, signs, histopathology.
  • Prognosis: very good; reversible on removal of excess steroid.

Pathogenesis

Etiology

  • Excessive steroid, either through exogenous administration or secondary to hyperadrenocorticism Hyperadrenocorticism.
  • Individual variation in response, different potencies of glucocorticoids, and route of exposure influence changes in hepatic morphology, clinicopathologic features, and clinical signs.

Specific

Pathophysiology

  • Excess glycogen accumulation in hepatocytes.

Timecourse

  • Depends on dose, route of exposure and potency of glucocorticoid.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Center S A, Warner K L, McCabe J, Foureman P, Hoffmann W E & Erb H N (2005) Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs. Am J Vet Res 66 (2), 330-341 PubMed.
  • Rutgers H C, Batt R M, Vaillant C & Riley J E (1995) Subcellular pathologic features of glucocortcoid-induced hepatopathy in dogs. Am J Vet Res 56 (7), 898-907 PubMed.

Other sources of information

  • Scherk M A & Center S A (2005)Toxic, Metabolic, Infectious, and Neoplastic Liver diseases. In:Textbook of Veterinary Internal Medicine. 6th edn. Eds: S J Ettinger & E C Feldman. Philadelphia: W B Saunders. pp 1464-1477.


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