Canis ISSN: 2398-2942

Liver: lobular dissecting hepatitis (Standard Poodle)

Contributor(s): Nick Bexfield

Introduction

  • Rare.
  • Standard poodle and some other breeds.
  • Cause: unknown.
  • Signs: ascites due to portal hypertension, chronic hepatitis Liver: chronic hepatitis.
  • Diagnosis: hepatic biopsy.
  • Treatment: supportive and symptomatic.

Pathogenesis

Etiology

  • This is an idiopathic inflammatory hepatitis. It is probably a response of the juvenile liver to a variety of insults rather than a diagnosis in itself. Infectious etiologies have been suggested.

Pathophysiology

  • Cumulative hepatic insult → functional reserve capacity exceeded (>70% damage) → failure to perform diverse metabolic functions → clinical signs.
  • Increased resistance to blood flow through liver due to hepatocytes swelling → development of portal hypertension →ascites. Ascites may also develop due to hypoalbuminemia Hypoproteinemia.
  • Acquired shunting vessels may develop due to sustained portal hypertension.

Timecourse

  • Unknown.

Epidemiology

  • Unknown.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Bennett A M, Davies J D, Gaskell C J et al (1983) Lobular dissecting hepatitis in the dog. Vet Pathol 20 (2), 179-188 PubMed.

Other sources of information

  • Center S A (1996)Chronic hepatitis, cirrhosis, breed-specific hepatopathies, copper storage hepatopathy, suppurative hepatitis and idiopathic hepatic fibrosis.In:Strombeck's Small Animal Gastroenterology. 3rd edn. Eds W G Guilfordet al. W B Saunders, Philadelphia, PA, USA. pp 755-756.


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