Canis ISSN: 2398-2942

Liver: idiopathic fibrosis

Synonym(s): Idiopathic hepatic fibrosis

Contributor(s): Nick Bexfield, James Simpson

Introduction

  • A hepatic disease of young dogs associated with a non inflammatory hepatopathy characterized by progressive fibrosis.
  • Young dogs present with anorexia, weight loss and ascites.
  • Many have signs of hepatic encephalopathy.

     

Pathogenesis

Etiology

  • Not known. However there is a suggestion of genetic predisposition as most common in GSDs; congenital disease Liver: congenital diseases.
  • May be caused by intra-hepatic portal vein hypoplasia.
  • Other suggestions include: toxins such as aflatoxin, pyrrolizidine alkaloids and immune-deficiency.

Pathophysiology

  • Progressive development of fibrosis within the liver leading to loss of liver function and progressive portal hypertension which leads to signs of liver failure and ascites respectively.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Bunch S E et al (2001) Idiopathic noncirrhotic portal hypertension in dogs: 33 cases (1982-1998). JAVMA 218 (3), 392-399 PubMed.
  • Van den Ingh T S et al (1995) Portal hypertension associated with primary hypoplasia of the hepatic portal vein in dogs. Vet Rec 137 (17), 424-427 PubMed.
  • Rutgers H C et al (1993) Idiopathic hepatic fibrosis in 15 dogs. Vet Rec 133 (5), 115-118 PubMed.

Other sources of information

  • Watson P J (2005)diseases of the liver.In:BSAVA Manual of Canine and Feline Gastroenterology. 2nd edn. Eds E J Hall, J W Simpson & S A Williams. BSAVA Publications. pp 240-268.
  • Rutgers C H (2000)Hepatic fibrosis in the dog.In: Kirk'sCurrent Veterinary Therapy. XIII edn. Ed J D Bonagura.W B Saunders, Philadelphia, USA. pp 677-681.


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