Canis ISSN: 2398-2942

Liver: cholangiohepatitis

Contributor(s): Nick Bexfield, Kyle Braund

Introduction

  • Uncommonly recognized in dogs.
  • Hepatitis due to edema and sluggish bile flow may be concurrent.
  • Cause: ascending infection.
  • Signs: hepatic disease with icterus: pyrexia, anorexia, vomiting and diarrhea, lethargy, weight loss, ascites.
  • Diagnosis: biochemistry, ultrasonography, gall bladder aspiration, biopsy.
  • Treatment: antibiotics, other supportive measures.
  • See also acute hepatic disease Liver: acute disease.

Pathogenesis

Etiology

Specific

  • Predisposing causes include:
    • Bile duct/gall bladder anomalies.
    • Intestinal abnormalities such as bacterial overgrowth.
    • Other small or large intestinal disorders such as motility disorders, clostridial disease.
    • Cholelithiasis.

Pathophysiology

 

Timecourse

  • Depends on etiology.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • O'Neill E J, Day M J, Hall E J, Holden D J, Murphy K F, Barr F J & Pearson G R (2006) Bacterial cholangitis/cholangiohepatitis with or without concurrent cholecystitis in four dogsJSAP 47 (6), 325-335 PubMed.
  • Center S A (1999) Chronic liver disease - current concepts of disease mechanisms. JSAP 40 (3), 106-114 PubMed.
  • Fuentealba C et al (1997) Chronic hepatitis - a retrospective study in 34 dogs. Can Vet J 38 (6), 365-373 PubMed.
  • Forrester S D, Rogers K S, Relford R L (1992) Cholangiohepatitis in a dog. JAVMA 200 (11), 1704-1706 PubMed.
  • Neer T M (1992) A review of disorders of the gallbladder and extrahepatic biliary tract in the dog and cat. J Vet Int Med 6 (3), 186-192 PubMed.

Other sources of information

  • Willard M D (2005)diseases of the gallbladder and extrahepatic biliary system. In:Textbook of Veterinary Internal Medicine. 6th edn. Eds: S J Ettinger & E C Feldman. Philadelphia: W B Saunders. pp 1478-1482.
  • Center S A (1996)diseases of the gall bladder and biliary tree.In:Strombeck's Small Animal Gastroenterology. 3rd edn. Eds: W G Guildfordet al. W B Saunders, Philadelphia, PA , USA. pp 860-877.


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