ISSN 2398-2969      

Kidney: polycystic disease

icanis
Contributor(s):

Phil Nicholls


Introduction

  • Uncommon condition, characterized by dilated nephron segments, fluid-filled involving the glomerular capsule or any portion of the renal tubules.
  • Cause: genetic or acquired.
  • Signs: asymptomatic or chronic renal failure, or symptoms due to infection of the cysts.
  • Diagnosis: abdominal enlargement, polydipsia, polyuria, pyrexia.
  • Treatment: antibiotics.
  • Prognosis: good to poor.

Pathogenesis

Etiology

  • Acquired (most common) due to microbes, drugs, toxins, etc.
  • Inherited.

Predisposing factors

General
  • Breed.

Pathophysiology

  • Acquiredpolycystic kidney disease → substantial tubulointerstitial inflammation and/or fibrosis → chronic renal failure.
  • Inheritedpolycystic kidney disease → cysts gradually enlarge → displace normal renal parenchyma → chronic renal failure.
  • Acquired and hereditary- cysts may be incidental finding, if only a small portion of renal tissue is affected.

Timecourse

  • Weeks to months.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

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