Canis ISSN: 2398-2942

Kidney: ischemia

Synonym(s): Renal ischaemia

Contributor(s): Phil Nicholls

Introduction

  • Cause: multiple potential events that can lead to renal ischemia.
  • Signs: shock, hyperthermia/hypothermia.
  • Diagnosis: depends on underlying cause.
  • Treatment: treat underlying cause.
  • Prognosis: acute renal failure if renal ischemia not corrected quickly.
  • See also renal failure Kidney: acute kidney injury (AKI).

Pathogenesis

Etiology

Pathophysiology

  • Renal ischemia → decreased intracellular ATP → decreased function of Na-K and Na-Ca ATP-ase pumps → increased intracellular Na and Ca → increased intracellular osmotic pressure → swelling of tubular cells and sludging and aggregation in renal blood vessels → further decrease in renal blood flow.
  • Renal ischemia → increase in oxygen free radical formation → further damage cell membranes.
  • Severe damage to the renal cells → acute renal failure.

Timecourse

  • Acute.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Cylwik B et al (1985) Histological and biochemical changes in the dog kidney after renal artery embolization with Spongostan. Int Urol Nephrol 17 (3), 203-210 SpringerLink.
  • Lalli A F et al (1973) Selective canine renal infarction. Cleve Clin Q 40 (2), 75-77 PubMed.


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