ISSN 2398-2969      

Kidney: dysplasia

icanis

Synonym(s): Renal dysplasia


Introduction

  • Cause: familial disease in certain breeds. Autosomal recessive inheritance in Shih Tzu and Soft-coated Wheaten Terrier.
  • Signs: same as chronic renal failure Kidney: chronic kidney disease (CKD) , eg polydipsia/polyuria, weight loss/poor growth usually at a young age, signs related to renal secondary hyperparathyroidism.
  • Diagnosis: history, signs, radiography, ultrasonography, biochemistry. Definitive diagnosis by histology. 
  • Treatment: supportive only.
  • Prognosis: variable depending on severity of the disease and degree of renal dysfunction. 

Pathogenesis

Etiology

  • Congenital. Autosomal recessive inheritance in Shih Tzu and Soft-coated Wheaten Terrier. 
  • Possible role of allelic variation in the promoter of the canine cyclooxygenase-2 (Cox-2) gene. 
  • Familial.

Predisposing factors

General

  • Breed.

Pathophysiology

  • Abnormal development of renal parenchyma → immature glomeruli and other inappropriate structures → renal failure.

Timecourse

  • Insidious in young puppies over weeks-months.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Whiteley M H, Bell J S, Rothman D A (2011) Novel allelic variants in the canine cyclooxgenase-2 (Cox-2) promoter are associated with renal dysplasia in dogs. PLoS One 6(2), e16684 PubMed
  • Bruder M C, Shoieb A M, Shirai N et al (2010) Renal dysplasia in Beagle dogs: four cases. Toxicol Pathol 38(7), 1051-1057 PubMed.  
  • Seiler G S, Rhodes J, Cianciolo R et al (2010) Ultrasonographic findings in Cairn Terriers with preclinical renal dysplasia. Vet Radiol Ultrasound 51(4), 453-457 PubMed.
  • Schulze C et al (1998) Renal dysplasia in three young adult Dutch Kooiker dogs. Vet Q 20 (4), 146-148 PubMed.
  • Felkai C, Vörös K, Vrabély T, Vetési F, Karsai F, Papp L (1997) Ultrasonographic findings of renal dysplasia in cocker spaniels: eight cases. Acta Vet Hung 45(4), 397-408 PubMed.
  • de Morais H S, DiBartola S P, Chew D J (1996) Juvenile renal disease in golden retrievers: 12 cases (1984-1994). J Am Vet Med Assoc 209(4), 792-797 PubMed

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