Canis ISSN: 2398-2942

Inherited myopathy (Great Dane)

Synonym(s): Central core myopathy, core-like myopathy

Contributor(s): G Diane Shelton

Introduction

  • Rare - seen in young Great Danes.
  • Distribution: UK, Australia, and Canada with most cases to date in the UK.
  • Signs: generalized weakness and exercise intolerance.
  • Prognosis: poor.

Pathogenesis

Pathophysiology

  • Muscle pathology → compromised muscle function → muscle atrophy → generalized weakness, exercise intolerance and stiff gait.
  • A specific mutation has not yet been identified.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Lujan Feliu-Pascual A, Shelton G D, Targett M P, Long S N, Comerford E J, McMillan C, Davies D, Rushbridge C, Mellor D, Chang K C & Anderson T J (2006) Inherited myopathy of great Danes. JSAP 47 (5), 249-254 PubMed.


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