Canis ISSN: 2398-2942

Immunology: canine leukocyte adhesion deficiency (CLAD)

Contributor(s): Michael Day

Introduction

  • Congenital immunodeficiency disease of Irish setters Irish Setter.
  • Cause: absence of two leucocyte surface glycoproteins: CD11b and CD18.
  • Neutrophilia but impaired neutrophil chemotaxis into tissue (pus formation).
  • Signs: increased susceptibility to bacterial infections.

Diagnosis

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Treatment

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Prevention

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Jobling A I, Ryan J & Auguesteyn R C (2003) The frequency of the canine leukocyte adhesion deficiency (CLAD) allele within the Irish Setter population of Australia. Aust Vet J 81 (12), 763-765 PubMed.
  • Debenham S L, Millington A, Kijast J, Andersson L & Binns M (2002) Canine leucocyte adhesion deficiency in Irish red and white setters. JSAP 43 (2), 74-75 PubMed.
  • Foureman P, Whiteley M & Giger U (2002) Canine leukocyte adhesion deficiency: presence of the CYS36Ser beta-2integrin mutation in an affected US Irish Setter cross-breed dog and in US Irish Red and White Setters. J Vet Intern Med 16 (5), 518-523 PubMed.
  • Trowald-Wigh G et al (2000) Clinical, radiological and pathological features of 12 Irish setters with canine leucocyte adhesion deficiency. JSAP 41 (5), 211-217 PubMed.
  • Trowald-Wigh G et al (1992) Leucocyte adhesion protein deficiency in Irish setter dogs. Vet Immunol Immunopathol 32 (3-4), 261-280 PubMed.
  • Giger U et al (1987) Deficiency of leukocyte glycoproteins Mo1, LFA-1 and Leu M5 in a dog with recurrent bacterial infections - an animal model. Blood 69 (6), 1622-30 PubMed.

Organisation(s)

  • Genetic Services,Animal Health Trust , Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK. Website:www.aht.org.uk


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