Canis ISSN: 2398-2942

Idiopathic pulmonary fibrosis

Synonym(s): Chronic fibrosing alveolitis, Cryptogenic pulmonary fibrosis, Chronic pulmonary disease of West Highland White Terriers, Interstitial lung disease in West Highland Terriers

Contributor(s): Chris Little

Introduction

  • Uncommon condition which has only briefly been described in the veterinary literature. Almost certainly under-reported.
  • Cause: unknown, apparently genetic.
  • Signs: dyspnea, cyanosis, hypoxia.
  • Diagnosis: lung biopsy. Presumptive diagnosis by breed, radiography/thoracic ultrasonography, blood gas analysis, and exclusion of other causes of chronic thoracic pathology.
  • Treatment: symptomatic only.
  • Prognosis: poor.

Pathogenesis

Pathophysiology

  • Expansion of the interstitial space of alveolar septae by extracellular matrix (ECM) consisting of a mixture of type-1 and type-111 collagens. Some similarities with human condition which is idiopathic.

Timecourse

  • Months compared with most other causes of severe interstitial lung pattern.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Norris A J, Naydan D K, Wilson D W (2005) Interstitial lung disease in West Highland White Terriers. Vet Pathol 42 (1), 35-41 PubMed.
  • Corcoran B M, Cobb M, Martin W S, Dukes-McEwan et al (1999) Chronic pulmonary disease in West Highland White Terriers. Vet Rec 144 (22), 611-616 PubMed.
  • Corcoran B M, Dukes-McEwan J, Rhind S & French A (1999) Idiopathic pulmonary fibrosis in a Staffordshire bullterrier with hypothyroidism. JSAP 40 (4), 185-188 PubMed.

Other sources of information

  • Corcoran B M (2004)Idiopathic Pulmonary Fibrosis.In:Textbook of Respiratory Disease in Dogs and Cats. Ed Lesley G King, Saunders/Elsevier. Chapter 77, pp 581-586.


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