Canis ISSN: 2398-2942

Hepatorenal syndrome

Contributor(s): Audrey K Cook

Introduction

  • Very uncommon in dogs.
  • Cause: unclear; rapid deterioration in kidney function associated with fulminant liver failure, either acute or chronic/end-staged.
  • Treatment: intensive supportive therapy.
  • Prognosis: very poor.

Pathogenesis

Etiology

Predisposing factors

General
  • Failure to support circulatory function in patient with fulminant hepatic failure.

Pathophysiology

  • Fulminant hepatitic failure → severe loss of liver function → hemorrhage, sepsis, circulatory shock → prerenal ischemia → intense renal vasoconstriction → acute tubular necrosis → azotemia, oliguria/anuria.

Timecourse

  • Acute.
  • Associated/underlying liver disease may be chronic.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers


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