Canis ISSN: 2398-2942

Gluten-sensitive enteropathy

Synonym(s): Wheat-sensitive enteropathy

Contributor(s): James Simpson, Kenneth Simpson

Introduction

  • Cause: sensitivity to dietary gluten, affecting young dogs, especially Irish Setter.
  • Signs: poor weight gain or weight loss with or without chronic diarrhea.
  • Diagnosis: biopsies show partial villous atrophy with some lymphocytic infiltration of lamina propria, intra-epithelial lymphocytes (IELs), increased intestinal permeability.
  • Treatment: gluten-free diet.
  • Prognosis: good if dietary control is strict.

Pathogenesis

Etiology

  • Dietary gluten.
  • Heritable disease in the Irish Setter.

Pathophysiology

  • Not well understood:
    • Dietary gluten → toxic or immunologic insult → partial villous atrophy and lymphocytic infiltration of lamina propria especially proximal small intestine.
    • Increased intestinal permeability after gluten challenge in affected dogs.

Timecourse

  • Upon exposure to dietary gluten.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Garden O A, Pidduck H et al (2000) Inheritance of gluten-sensitive enteropathy in Irish Setters. Am J Vet Res 61 (4), 462-468 PubMed.
  • Garden O A et al (1998) Intestinal permeability of Irish setter puppies challenged with a controlled oral dose of gluten. Res Vet Sci 65 (1), 23-28 PubMed.
  • Marks S L (1998) Management of canine inflammatory bowel disease. Comp Cont Ed Pract Vet 20 (3), 317-332 VetMedResource.
  • Guilford W G (1994) Adverse reactions to foods - a gastrointestinal perspective. Comp Cont Ed Pract Vet 16 (8), 957-69 VetMedResource.
  • Batt R M & Hall E J (1989) Chronic enteropathies in the dog. JSAP 30 (1), 3-12 VetMedResource.


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