ISSN 2398-2969      

Fibrosarcoma

icanis

Synonym(s): FSA


Introduction

  • Malignant, locally invasive tumor of mesenchymal cells.
  • Sites: axial skeleton and flat bone (pelvis and scapular), subcutaneous tissues anywhere on body, mouth, nasal cavity.
  • Signs: firm, subcutaneous mass; may involve underlying skeletal muscle or bone.
  • Metastasis - uncommon.
  • Diagnosis: histopathology, radiography/CT scan, cytology.
  • Treatment: amputation/wide surgical resection, aiming for 3-5 cm margins around tumor and on fascial plane deep to gross tumor (difficult - invasive).
  • Prognosis: recurrence rate high following incomplete resection - better following amputation.

Pathogenesis

Etiology

  • Unknown.
  • Radiation, trauma, foreign bodies, orthopedic implants, and the parasite Spirocerca lupi Canine spirocercosis have been associated with sarcomas.

Pathophysiology

  • Variants:
    • Malignant fibrous histiocytoma: neoplasia of mesenchymal cells arising in same potential sites as FSA.
    • Also occurs as a giant, multinucleated cell variant.
  • Locally invasive tumor may → extension to surrounding tissues/bone → bone destruction/proliferation.
  • Metastasis - uncommon (depend on the grade).

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Frazier S A, Johns S M, Ortega J, Zwingenberger A L, Kent M S, Hammond G M, Rodriguez C O Jr, Steffey M A, Skorupski K A (2012) Outcome in dogs with surgically resected oral fibrosarcoma (1997-2008). Vet Comp Oncol 10 (1), 33-43 PubMed.
  • Dennis M M, McSporran K D, Bacon N J, Schulman F Y, Foster R A, Powers B E (2011) Prognostic factors for cutaneous and subcutaneous soft tissue sarcomas in dogs. Vet Pathol 48 (1), 73-84 PubMed.
  • McChesney S L, Withrow S J et al (1989) Radiotherapy of soft tissue sarcomas in dogs. JAVMA 194 (1), 60-63 PubMed.
  • Weinstein M J, Carpenter J L et al (1989) Nonangiogenic and nonlymphomatous sarcomas of the canine spleen - 57 cases (1975-1987). JAVMA 195 (6), 784-788 PubMed.

Other sources of information

  • Withrow S J, Vail D M, Page R L (2013)Small Animal Clinical Oncology.5th edn. Elsevier.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code