Canis ISSN: 2398-2942

Enteritis: lymphocytic plasmacytic

Introduction

  • A form of inflammatory bowel disease involving the small and/or large intestine.
  • Cause: etiology obscure - perhaps immune-mediated sensitivity to range of antigens, eg diet, parasite, bacteria, etc.
  • Signs: chronic vomiting, diarrhea and weight loss.
  • Diagnosis: intestinal biopsy and histopathology (infiltration of lamina propria by lymphocytes and plasmacytes).
  • Treatment: hypoallergenic diet, corticosteroids or other immunosuppressive drugs.
  • Prognosis: can be good although may require life-long therapy.

Pathogenesis

Etiology

  • Unknown.
  • Genetic, bacterial, immunological and mucosal permeability factor likely.
  • Some dogs respond to hypoallergenic diets, anti-Giardial drugs or antibiotics against intestinal bacteria.

Predisposing factors

General

Pathophysiology

  • Hypothesized hypersensitivity to antigen(s) → chronic inflammation → loss of mucosal integrity and increased permeability → antigens can access lamina propria → further immune reaction and inflammation → malabsorption → protein-losing enteropathy.
  • May be a non-specific reaction to a variety of agents.
  • Loss of immune tolerance.
  • Infiltration of lamina propria by inflammatory cells → malabsorption → may also affect permeability of mucosal barrier allowing further antigenic stimulation → protein losing enteropathy.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Jergens A E, Moore F M, Haynes J S & Miles K G (1992) Idiopathic inflammatory bowel disease in dogs and cats: 84 casesJAVMA 201 (10), 1603-1608 PubMed.
  • Jacobs G, Collins-Kelly L, Cappin M & Tyler D (1990) Lymphocytic and plasmacytic enteritis in 24 dogs. J Vet Int Med 4 (2), 45-53 PubMed.
  • Rutgers H C, Batt R M, & Kelly D F (1988) Lymphocytic-plasmacytic​ enteritis associated with bacterial overgrowth in dogs. JAVMA 192 (12), 1739-1742 PubMed.


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