ISSN 2398-2969      

Copper toxicosis (Bedlington Terrier)

icanis
Contributor(s):

Kyle Braund


Introduction

  • Excessive storage of copper in liver.
  • Cause: autosomal recessive.
  • Signs: liver failure (acute or chronic), rarely hemolytic crisis.
  • Diagnosis: liver biopsy.
  • Treatment: supportive, eg diet; copper chelating agents, eg D-penicillinamine.
  • Prognosis: reasonable, some → cirrhosis.
  • See also: Acute liver disease Liver: acute disease.

Pathogenesis

Etiology

  • Autosomal recessive.

Pathophysiology

  • An inherited metabolic defect in biliary copper excretion caused by abnormal binding of copper with metalothionein in the liver.
  • The hepatic injury involves oxidant damage to hepatic mitochondria.
  • Genetic trait → hepatocytes accumulate copper (massive liver copper accumulation) → hepatocytes die → hepatocytes replaced by fibrosis → hepatic failure. Hepatitic damage does not consistently occur until copper concentrations exceed 2000 ug/g.
  • Rare: lysis of large numbers of hepatocytes → massive hemolysis.

Timecourse

  • Variable.
  • Affected dogs can be symptomatic or show signs of acute hepatic necrosis, chronic hepatitis or cirrhosis.

Diagnosis

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Prevention

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Holems N G et al (1998) DNA marker C04107 for copper toxicosis in a population of Bedlinton Terriers in the United Kingdom. Vet Rec 142 (14), 351-352 PubMed.
  • Yuzbagiyan-Gurkan V et al (1997) Linkage of a microsatellite marker to the canine copper toxicosis locus in Bedlington Terriers. Am J Vet Res 58 (1), 23-27 PubMed.

Other sources of information

  • Johnson S E (2000)Chronic hepatic disorders.In:Textbook of Veterinary Internal Medicine. 5th edn. Eds: S J Ettinger & E C Feldman. Philadelphia: W B Saunders. pp 1298-1325.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code