ISSN 2398-2969      

Colitis: histiocytic ulcerative/granulomatous/Boxer

icanis
Contributor(s):

Audrey K Cook


Introduction

  • Rare, usually seen in young adult Boxers and French bulldogs.
  • Cause: chronic mucosal infection with invasiveEscherichia coli.
  • Signs: fecal tenesmus, fecal blood and mucus, increased frequency of defecation; weight loss.
  • Diagnosis: requires colonic biopsy; classic findings include numerous periodic-acid Schiff-positive histiocytes in the lamina propria.
  • Treatment: enrofloxacin is usually effective.
  • Prognosis: good with prompt appropriate treatment.

Pathogenesis

Etiology

  • Chronic mucosal infection with invasiveEscherichia coli Escherichia coli.
  • Profound genetic predisposition suggests inherent susceptibility within certain breeds.

Pathophysiology

  • Mucosal damage by invasiveE. coli→ inflammatory response → abnormal motility and failure to absorb fluid and electrolytes from feces; also deranged colonic motility → increased frequency of defecation.
  • Inflammation → stimulation of Goblet cells → production of excessive mucus.
  • Rectal inflammation → urgency to defecate and inability to hold stool.
  • Vomiting observed in 30% of cases due to colonic inflammation, NOT gastric.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Craven M, Dogan B, Schukken A et al (2010) Antimicrobial resistance impacts clinical outcome of granulomaatous colitis in boxer dogs. JVIM 24, 819-824 PubMed.
  • Mansfield C S, James F E, Craven M et al (2009) Remission of histiocytic ulcerative colitis in boxer dogs correlates with eradication of invasive intramucosal Escherichia coli. JVIM 23, 964-969 PubMed.
  • Hostutler R A, Luria B J, Johnson S E et al (2004) Antibiotic-reponsive histiocytic ulcerative colitis in 9 dogs. JVIM 18, 499-504 PubMed.

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