Canis ISSN: 2398-2942

Brush border membrane disease

Contributor(s): Rance Sellon, James Simpson

Introduction

  • Cause: primary deficiencies of brush border enzymes, eg lactase, sucrase - mainly theoretical in dogs.
  • Secondary deficiencies of disaccharidase, brush border peptidase due to bacterial overgrowth or small intestinal diseases, eg eosinophilic enteritis, lymphocytic enteritis.
  • Signs: chronic diarrhea.
  • Prognosis: good with treatment.

Pathogenesis

Etiology

  • Small intestinal diseases.
  • Deficiency of specific brush border enzymes.

Predisposing factors

General

Pathophysiology

  • Small intestinal mucosal damage→ reduction in activity of disaccharidase/brush border peptidase → malabsorption of disaccharides/oligopeptides.
  • Specific deficiency of brush border enzyme, ie lactase, sucrase, enterokinase, other peptidases → malabsorption of lactose/sucrose and protein.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Pemberton P W et al (1997) An aminopeptidase N deficiency in dog small intestine. Res Vet Sci 63 (2), 133-8 PubMed.
  • Fyfe J C et al (1991) Defective brush-border expression of intrinsic factor-cobalamin receptor in canine inherited intestinal cobalamin malabsorption. J Biol Chem 266 (7), 4489-4494 PubMed.
  • Batt R M (1990) Relationship between diet and malabsorption in dogs. JSAP 31 (10), 489-493 VetMedResource.
  • Batt R M (1989) Chronic enteropathies in the dog. JSAP 30 (1), 3-12 VetMedResource.

Other sources of information

  • Harris J Tet al(1985)Congenital and inherited defects of enterocytes.In:Disorders of the Small Intestine.Booth C C, Neale G (editors), Blackwells, Oxford. p52.


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