Canis ISSN: 2398-2942

Bile acid deficiency

Contributor(s): Ben Harris, James Simpson

Introduction

  • Rare, as large reserve capacity for hepatic production.
  • Cause: hepatic failure, cholangitis with cholestasis or bile duct obstruction.
  • Diagnosis: fat absorption test repeated with addition of bile acids. (Rarely needed: presumptive in cases of hepatic failure and obstructive jaundice.) Imaging biliary tract.
  • Treatment: management of underlying disease.
  • Prognosis: guarded.

Pathogenesis

Etiology

  • Hepatic failure resulting in decreased production of bile acids.
  • Cholangitis.
  • Note: large reserve capacity for production of bile acids and only very small quantities required for physiological purposes, therefore rare.
  • Obstruction of bile duct, eg by bile duct, pancreatic Pancreas: neoplasia or duodenal neoplasm Small intestine neoplasia , pancreatic phlegmon or pseudocyst.

Specific

Pathophysiology

  • Reduced bile acid concentrations in duodenum → decreased emulsification of fat → impaired fat digestion → impaired absorption of fat → chronic diarrhea.

Timecourse

  • Acute or gradual onset - acute or chronic course.

Diagnosis

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Treatment

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Outcomes

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Batt R M (1990) Relationship between diet and malabsorption in dogs. JSAP 31 (10), 489-493 VetMedResource.
  • Simpson J W, Van den Broek A (1989) Deficiency of bile salts causing steatorrhoea and weight loss in 2 dogs. JSAP 30 (10), 567-569 VetMedResource.

Other sources of information

  • Sevelius E & Jonsson L (1996)Liver Disease.In:BSAVA Manual of Canine and Feline Gastroenterology.Thomas D, Hall E & Simpson J (editors). BSAVA, Cheltenham.


ADDED