Bovis ISSN 2398-2993

Erythromycin

Synonym(s): Macrolide antimicrobial

Contributor(s): Louise Cox-O’Shea, Vetstream Ltd , Andrea Tarr

Introduction

Name

  • Erythromycin.

Class of drug

  • Macrolide antimicrobial.

Description

Molecular formula

  • C₃₇H₆₇NO₁₃

Molecular weight

  • 733.93 g/mol.

Uses

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Indications

  • Erythromycin-sensitive infections:
    • Especially Campylobacter spp - drug of choice Campylobacter spp.
    • Streptococci Streptococcus spp.
    • Staphylococcus aureus - including penicillin-resistant strains Staphylococcus spp.
    • Gram-negative bacteria.
    • Anerobes.
    • Rhodococcus spp.
    • Clinical and subclinical mastitis in cattle.
    • Bacterial eye infections (not licensed in cattle).
    • Less active against Mycoplasma spp.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Most of the following drugs are not used/ licensed in cattle. This information has been included for completeness. Please always check the specific product information and ensure that you comply with local rules.
    • Digoxin: Digoxin
      • May enhance absorption of digoxin from the GI Tract.
    • Methylprednisolone: Prednisolone
      • May increase serum levels of methylprednisolone.
    • Theophylline:
      • May increase serum levels of theophylline.
    • Terfenadine:
      • May increase serum levels of terfenadine - in humans lead to fatal arrhythmias.
    • Warfarin:
      • May increase serum levels of warfarin.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Bishop Y (2006) The Veterinary Formulary 6th edn. Published in association with the British Veterinary Association.

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