ISSN 2398-2993      

Enrofloxacin

obovis

Introduction

Name

  • Enrofloxacin.

Class of drug

  • Antibiotic.
  • Antimicrobial.
  • Fluoroquinolone.

Description

Chemical name

  • 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid.

Molecular formula

  • C19H22FN3O3.

Molecular weight

  • 359.40.

Physical properties

  • Available as clear, yellow coloured, solution for injection.
  • Oral solution. 

Storage requirements

  • <25°C.
  • Do not freeze.
  • Use or discard within 28 days of opening.
  • In a dry environment.

Uses

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Indications

  • Enrofloxacin sensitive infections.
  • Bovine respiratory disease caused by Mannheimia haemolytica Mannheimia haemolytica, Pasteurella multocida Pasteurella multocida, Haemophilus somnus Haemophilus somnus & Mycoplasma spp.
  • Treatment of acute/ peracute mastitis caused by E. coli E. coli in lactating dairy cattle where herd health history and sensitivity testing indicate its use. 
  • Alimentary tract infections caused by E. coli.
  • Treatment of bacterial infections secondary to viral conditions.
  • Enrofloxacin is effective against many beta-lactamase producing bacteria.
Not effective against anaerobic infections.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

Antibiotics

Combination with Chloramphenicol, macrolide antibiotics or tetracyclines may produce antagonistic effects.

Adsorbents and antacids containing cations (Mg, Al)

  • May bind to fluoroquinolones and prevent its absorption; separate doses of these drugs by 2 hrs.

Sucralfate and zinc salts

  • May inhibit absorption; separate doses of these drugs.
Theophylline
  • Increases plasma theophylline levels (in humans) - monitor carefully.
NSAIDs (non-steroidal Anti-inflammatory drugs Anti-inflammatory drugs
  • Potential pharmacodynamic interactions in the CNS could lead to seizures (in susceptible animals).
Probenecid
  • Blocks the tubular secretion of fluoroquinolones and may increase circulating concentrations and half-life.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed.

Other sources of information

  • Bishop Y (2005) Ed The Veterinary Formulary. 6th edn. Pharmaceutical Press. ISBN: 0-85369-579-2.
  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk. pp 47-48, 235- 238, 294- 295.
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