ISSN 2398-2993      

Dihydrostreptomycin

obovis

Introduction

Name

  • Dihydrostreptomycin.

Class of drug

  • Aminoglycoside antibacterial.

Description

Molecular formula

  • C₂₁H₄₁N₇O₁₂.

Molecular weight

  • 583.59 g/mol.

Storage requirements

  • Intramammary tubes:
    • Store at temperatures below 25°C.
    • Shake preparation thoroughly.
    • Intramammary tubes to be used once- any unused product should be disposed of.
  •  Injectable:
    • store in refrigerator between 2 & 8°C.
    • Protect from light.
    • Shake thoroughly.
    • Use/discard product within 28 days of withdrawing first dose.

Uses

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Indications

  • Dihydrostreptomycin-sensitive infections.
  • Mainly includes Gram-negative organisms and some Gram-positives but not streptococci.
  • Ineffective against anaerobes.
  •  Systemic infections.
  •  When combined with penicillin Penicillin useful in the treatment of gram +ve and gram -infections.
  •  Intramammary tubes: treatment of mastitis in lactating cows.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Synergistic with beta-lactam antibacterials and often administered in a compound preparation in conjunction with a penicillin Penicillin G.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Bishop Y (2006) The Veterinary Formulary 6th edn. Published in association with the British Veterinary Association.
  • NOAH compendium of datasheets.
  • VMD product database.
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