ISSN 2398-2993      

Botulism antitoxin

obovis

Synonym(s): Botulism antiserum


Introduction

Name

  • Botulism antitoxin.

Class of drug

  • Immunologic preparation.
  • Botulism antitoxin (equine) heptavalent contains purified F(ab′)2 and F(ab′)2-related immune globulin fragments prepared from equine plasma and has antitoxin activity against botulinum neurotoxins A, B, C, D, E, F, and G.
This is a human medical product and is not licensed for use in cattle.

Description

Physical properties

  • Usually provided in single use vials.
  • Each single-use vial of Botulism Antitoxin (Equine) (regardless of vial size or fill volume) contains at least 4500, 3300, 3000, 600, 5100, 3000, and 600 units of serotype A, B, C, D, E, F, and G antitoxin, respectively.

Storage requirements

  • May be delivered as a frozen product or thawed.

Uses

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Indications

  • Botulism Botulism: definitive diagnosis depends on demonstration of the specific toxin in source material and/or serum.
  • The administration of antiserum is of limited value in advanced stages of the disease but may be considered as a prophylactic measure in herds in which an outbreak has just started.
  • This treatment is very expensive and so treatment is likely to be reserved for only the most valuable breeding stock.
Antiserum is difficult to obtain (generally from human hospitals).

Administration

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Pharmacokinetics

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Braun U (2006) Botulism in cattle. Schweiz Arch Tierheilkd 148 (7), 331-339 PubMed.

Other sources of information

  • Drugs.com (2019) Botulism Antitoxin (Equine). Website: www.drugs.com
  • The Center for Food Security and Public Health (2018) Botulism. Iowa State University of Science and Technology, USA. Website: www.cfsph.iastate.edu (pdf download).
  • Knottenbelt D K & Malalana F (2014) Formulary of Equine Medicine. 2nd edn. Liverpool University Press, UK. ISBN: 0-85323-740-9.
  • Bishop Y (2004) The Veterinary Formulary. 6th edn. British Veterinary Association and Royal Pharmaceutical Society, UK.
  • FDA (online) FDA Adverse Event Reporting System (FAERS). Available at: www.fda.gov.
  • NOAH (online) Adverse Reactions Reporting Forms. Available at: www.noahcompendium.co.uk.
  • VMD (online) Animal Adverse Reaction Reporting. Available at: www.vmd.defra.gov.uk.
  • VMD (online) Suspected Adverse Reaction Surveillance Scheme (SARSS). Available at: www.vmd.defra.gov.uk.
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