ISSN 2398-2993      

Ichthyosis

obovis
Contributor(s):

Catherine Fraser

Ben Dustan

Synonym(s): Fishscale disease


Introduction

  • Cause: rare congenital skin disease of cattle.
  • Signs: extreme hyperkeratosis on all or part of skin. Excessive cutaneous scaling and/or adherent plaques. Skin fissuring.
  • Diagnosis: clinical signs, age of onset, histopathology.
  • Treatment: none.
  • Prognosis: grave.

Pathogenesis

Etiology

  • Autosomal recessive inherited disease.
  • Causal gene mutations not yet identified.

Pathophysiology

  • Congenital.
  • A range of pathophysiological defects may be present depending on breed affected, including epidermal hyperproliferation, abnormal keratin production, faulty lipid formation, microtia and cataracts, eclabium and ectropion.
  • Alterations in desquamation of stratum corneum.
  • Decrease in epidermal cell turnover time.

Timecourse

  • Ichthyosis fetalis: calves are born dead or die within a few days.
  • Ichthyosis congenita: signs may be present at birth or appear over several weeks after birth.

Epidemiology

  • Simple autosomal recessive trait.
  • Affects approximately 25% of offspring when both parents are carriers.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Testoni S et al (2006) Ichthyosis in 2 Chianina Calves. Dtsch Tierartztl Wochenschrer 113 (9) 351-354 VetMedResource.
  • Molteni L et al (2006) Ichthyosis in Chianina Cattle. Vet Rec 158 (12) 412-414 PubMed.

Other sources of information

  • Scott D W (1988) Large Animal Dermatology. W B Saunders.

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