Felis ISSN 2398-2950

Anagen defluxion

Synonym(s): Anagen effluvium

Contributor(s): David Scarff

Introduction

  • Rare syndrome characterized by widespread excessive hair shedding.
  • Cause: chemotherapy or catastrophic disease   →   damages shaft of growing hairs.
  • Treatment: none.
  • Prognosis: good.

Pathogenesis

Etiology

  • Interference with anagen by antimitotic drugs, infectious diseases, metabolic diseases.

Predisposing factors

General

  • Catastrophic disease.
  • Chemotherapy.

Specific

  • Antimitotic drugs, eg cyclophosphamide Cyclophosphamide.
  • Infectious diseases, eg causes of severe acute pyrexia.
  • Metabolic diseases with severe and acute onset.

Pathophysiology

  • Catastrophic disease or chemotherapy   →   interferes with anagen phase of hair growth   →   abnormalities of hair follicle and shaft   →   break easily   →   excessive hair loss within days of insult.

Diagnosis

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Outcomes

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Further Reading

Publications

Refereed papers


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