Canis ISSN: 2398-2942

Hematology: monocyte

Synonym(s): Mononuclear phagocyte

Contributor(s): Kathleen P Freeman

Overview

  • Monocytes circulate in the blood briefly → enter the tissues → transform into macrophages → do not re-enter the circulation.
  • The ratio of circulating monocytes to macrophages is ~ 1:400.
  • The mononuclear phagocyte system (bone marrow precursors, monocytes and macrophages) phagocytoses and destroys microorganisms, phagocytoses particulate material (foreign bodies, tissue and cellular debris), interacts with lymphocytes in immune reactions, produces interferon and regulates hematopoiesis.

Sampling

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Tests

Methodologies

  • Manual hemocytometer - accuracy +/- 20-25%.
  • Electronic counting systems - accuracy +/- 3-5% (intralaboratory precision) or +/- 10-15% (interlaboratory precision).
  • Some in-practice analyzers or cell counting methods available.

Availability

  • Widely available at commercial laboratories.
  • May be performed in practice.

Validity

Sensitivity

  • Sensitive.

Specificity

  • Non-specific.

Predictive value

  • Useful if used in conjunction with differential white blood cell counts.

Technician (extrinsic) limitations

  • Some experience is required for accurate identification of leukocytes.

Result Data

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Further Reading

Publications

Refereed papers

Other sources of information

  • Cowell R L, Tyler R D & Meinkoth J H (1999) Diagnostic Cytology and Hematology of the Dog and Cat. 2nd edn. Mosby, St Louis.
  • Duncan J R, Prasse K W & Mahaffy E A (1994) Veterinary Laboratory Medicine Clinical Pathology. 3rd edn. Iowa University Press, Ames, Iowa.
  • Jain N C (1993) Essentials of Veterinary Hematology. Lea & Febiger, Philadelphia.


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