Canis ISSN: 2398-2942

Hematology: eosinophil

Contributor(s): Kathleen P Freeman, Simon Tappin

Overview

  • Eosinophils are generally involved in inflammatory processes in the body. Primarily involved in killing parasites or regulating the intensity of hypersensitivity reactions.
  • Eosinopoiesis stimulated by specific mediators including IL-5 and GM-CSF.
  • Attracted into tissue primarily by histamine (mast cells and basophils) and lymphokine (lymphocytes) to neutralize histamine, serotonin and bradykinin resulting in an anti-inflammatory effect. Peroxidase, present in specific eosinophilic granules, exert some anti-inflammatory effect at sites of antigen-antibody interaction, even when histamine is not involved.
  • Other functions are fibrin degradation (profibrinolysin produced by developing eosinophils in the bone marrow), phagocytosis and detoxification.
  • Kinetics: reservoir of 300-400 eosinophils in bone marrow (75% mature) for every one in circulating blood.
  • Lifespan in circulation is very variable from minutes to hours.

Sampling

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Tests

Methodologies

Availability

Technician (extrinsic) limitations

  • Some experience is required for accurate identification of leukocytes.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Sykes J E, Weiss D J, Buoen L C et al (2001) Idiopathic hypereosinophilic syndrome in 3 Rottweilers. JVIM 15, 162-166.

Other sources of information

  • Valenciano A C & Cowell R E (2013) Diagnostic cytology and hematology of the dog and cat. 4th edn. St Louis: Mosby.
  • Day M & Kohn B (2012) BSAVA Manual of Canine and Feline Haemotology and Transfusion Medicine. 2nd edn BSAVA.
  • Latimer K S (2011) Duncan and Prasse's Veterinary Laboratory Medicine: Clinical Pathology. 5th edn. Iowa University Press, Ames, Iowa.
  • Stockham S L & Scott M A (2008) Fundamentals of Veterinary Clinical Pathology. 2nd edn. Blackwell Publishing.


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