Canis ISSN: 2398-2942

Hematology: basophil

Contributor(s): Kathleen P Freeman

Overview

  • Rarely seen in circulating blood, hence presence is significant.
  • Promote inflammatory and allergic (immediate and delayed hypersensitivity) reactions by release of mediators such as histamine, heparin, serotonin and hyaluronic acid.
  • Difficult to distinguish from circulating mast cells in mast cell tumors Skin: mastocytoma. Distinguish by segmented nucleus (basophils) versus ovoid to round nucleus (mast cells).

Sampling

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Tests

Methodologies

  • Manual hemocytometer - accuracy +/- 20-25%.
  • Electronic counting systems - accuracy +/- 3-5% ( intralaboratory precision) +/- 10-15% (interlaboratory precision).
  • QBC-V hematology system.

Availability

  • Widely available at commercial laboratories.
  • May be performed in practice.

Validity

Sensitivity

  • Sensitive.

Specificity

  • Non-specific.

Predictive value

  • Useful if used in conjunction with differential white blood cell counts.

Technician (extrinsic) limitations

  • Some experience is required for accurate identification of leukocytes.

Result Data

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Further Reading

Publications

Refereed papers

Other sources of information

  • Cowell R L, Tyler R D & Meinkoth J H (1999) Diagnostic Cytology and Hematology of the Dog and Cat. 2nd edn. Mosby, St Louis.
  • Duncan J R, Prasse K W & Mahaffy E A (1994) Veterinary Laboratory Medicine Clinical Pathology. 3rd edn. Iowa University Press, Ames, Iowa.
  • Jain N C (1993) Essentials of Veterinary Hematology. Lea & Febiger, Philadelphia.


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