Canis ISSN: 2398-2942


Contributor(s): Ian Battersby, Jo Murrell, Simon Platt



  • Gabapentin.

Class of drug

  • Anti-epileptic drug (GABA[gamma-aminobutyric acid] agonist) - analog of GABA.


Chemical name

  • 1-(aminomethyl) cyclohexaneacetic acid.

Storage requirements

  • Store at room temperature.
  • Liquid form store in refrigerator.


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  • Adjunctive treatment of generalized seizures that are considered refractory to phenobarbitone Phenobarbital and potassium bromide Potassium bromide.
  • Adjunctive gabapentin therapy will reduce frequency of generalized seizures Seizures in over approximately 45% of idiopathic epileptic Epilepsy: idiopathic dogs refractory to phenobarbitone and potassium bromide therapy.
  • Adjunctive treatment of partial seizures Seizures with or without secondary generalization not satisfactorily controlled with other anti-epileptics Therapeutics: nervous system.
  • Management of neuropathic pain in man, for example painful diabetic neuropathy or post herpetic neuralgia.
  • Prevention of Chronic Post Surgical Pain in man.
  • Reduction in acute post-surgical pain in man.
  • The efficacy of gabapentin to treat neuropathic or acute post surgical pain in dogs is poorly documented and largely anecdotal or based on published case reports involving very few animals.


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with other drugs

  • None confirmed with any other anti-convulsants Therapeutics: nervous system but it may prolong half-life of felbamate Felbamate by 50% when the two drugs are used together.
  • Oral clearance may decrease when given with cimetidine Cimetidine.
  • Does NOT reduce the MAC of isoflurane in cats, this is likely also the case in dogs.

with diagnostic tests

  • Can give false positive urine protein tests (human data).
  • May also give rise to altered liver function tests in humans. Not known in dogs or cats.

Adverse Reactions

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Further Reading


Refereed papers

  • Recent references fromVetMedResourceandPubMed.
  • Aghighi S A, Tipoid A, Piechotta M, Lewczuk P, Kastner S (2012)Assessment of the effects of adjunctive gabapentin on postoperative pain after intervertebral disc surgery in dogs.VAA39, 636-646PubMed.
  • Plessas I N, Rusbridge C, Driver C J, Chandler K E, Craig A, McGonnell I M, Brodbelt D C, Volk H A (2012)Long term outcome of Cavalier King Charles Spaniel dogs with clinical signs associated with Chiari-like malformation and syringomyelia.Vet Record171,501PubMed.
  • Wagner A E, Mich P M, Uhrig S R, Hellyer P (2010)Clinical evaluation of perioperative administration of gabapentin as an adjunct for post-operative analgesia in dogs undergoing amputation of a forelimb.JAVMA236,751-756PubMed.
  • Pypendop B H, Siao K T, Ilkiw J E (2010)Thermal antinociceptive effect of orally administered gabapentin in healthy cats.Am J Vet Res71, 1027-1032PubMed.
  • Reid P, Pypendop B H, Ilkiw J E (2010)The effects of intravenous gabapentin administration on the minimum alveolar concentration of isoflurane in cats.Anaesth Analg111, 633-637.
  • Cashmore R G, Harcourt-Brown T R, Freeman P M, Jeffery N D (2009)Clinical diagnosis and treatment of suspected neuropathic pain in three dogs.Aust Vet J87, 45-50PubMed.
  • Hachad H, Ragueneau-Majlessi I and Levy R H (2002)New antiepileptic drugs: review on drug interactions.Therapeut Drug Monitoring.24,91-103.PubMed
  • Jensen A A, Mosbacher J, Elg Set al(2002)The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.Molec Pharmacol.61,1377-1384.PubMed
  • Honmou O, Kocsis J D and Richerson G B (1995)Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro.Epilepsy Res.20,193-202.PubMed
  • Radulovic L L, Turck D, Von Hodenberg Aet al(1995)Disposition of gabapentin (neurontin) in mice, rats, dogs, and monkeys.Drug Metab Dispos.23,441-448.PubMed
  • Macdonald R L and Kelly K M (1993)Antiepileptic drug mechanisms of action.Epilepsia.34 Suppl 5,S1-S8.

Other sources of information

  • Clarke H, Bonin R P, Orser B A, Englesakis M, Wijeysunder DN (2012)The prevention of Chronic Postsurgical Pain using gabapentin and pregabalin: a combined systematic review and meta-analysis.Anaesth Analgesia115, 428-442
  • Weinbroum A A (2012)Non-opioid IV adjuncts in the peri-operative period: pharmacological and clinical aspects of ketamine and gabapentinoids.Pharmacological Research65, 411-429.
  • Platt S R, Adams V, Garosi L, Abramson C J & Penderis J (2003)Gabapentin as adjunctive therapy for refractory idiopathic epilepsy in dogs.Proc 15th Ann ECVN Symp. Prague.