Canis ISSN: 2398-2942

Erythromycin

Synonym(s): Erythromycin A

Introduction

Name

  • Erythromycin.

Class of drug

  • Macrolide antibiotic.

Description

Molecular formula

  • C37H67NO13.

Physical properties

  • Tablets.
  • Solution.
  • Powder.

Uses

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Indications

  • Has similar, although not identical, antibacterial spectrum to penicillins.
  • Gram-positive infections.
    SomeStaphylococci Staphylococcus spp are resistant - can be quite high
  • Gram-positive bacilli and some gram-negative infections, egPasturellaspp.
  • Some strains ofActinomyces,Nocardia Nocardia spp ,Chlamydia Pseudomonas andRickettsia Escherichia coli.
    Most strains of the enterobacteriaceae, egPseudomonasspp,Escherichia coli,Klebsiellaspp, are resistant
  • Penetrates soft tissues including skin; useful in treatment of prostatitis Acute prostatitis.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Methylprednisolone
TheophyllineTerfenadine
  • Erythromycin may increase serum levels. In humans the interaction with terfenadine has led to fatal arrhythmias Terfenadine.
Warfarin
  • Erythromycin may increase serum levels Warfarin.
Digoxin
  • Erythromycin may enhance the absorption of digoxin from the GIT Digoxin.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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