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Povidone-iodine

obovis
Contributor(s):

Vetstream Ltd

Mike Reynolds

Synonym(s): PVP-1, iodopovidone, polyvinylpyrrolidone-iodinecomplex (povidone)


Introduction

Name

  • Povidone-iodine.

Class of drug

  • Topical antiseptic.
  • Topical germicide.
  • Topical antifungal agent.
  • Anti-protozoal.
  • Anti-viral.

Description

Chemical name

  • 1-ethenyl-2-pyrrolidinone homopolymer compound + iodine.
  • 1-vinyl-2-pyrrolidinone polymers, iodine complex.
  • polyvinylpyrrolidone-iodine complex (povidone).

Molecular formula

  • C6H9I2NO.

Molecular weight

  • 364.95 g/mol.

Physical properties

  • Iodophor solution containing a water-soluble complex of iodine and polyvinylpyrrolidone.

Uses

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Indications

  • Aseptic preparation of surgical sites.
  • Treatment of localized bacterial and fungal infections.
  • Teat dip.
  • Navel dip.
  • Uterine lavage Uterine lavage.
  • Wound disinfectant.

Administration

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Pharmacokinetics

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Precautions

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Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Rumika Y et al (2020) Intrauterine infusion of povidone-iodine: Its effect on the endometrium and subsequent fertility in postpartum dairy cows. J Vet Med Sci 82 (7), 926-934 PubMed.
  • Bigliardi P L et al (2017) Povidone iodine in wound healing: A review of current concepts and practices. Int J Surg 44, 260-268 PubMed.
  • Shogo M et al (2016) Effects of intrauterine infusion of povidone-iodine on endometrial cytology and bacteriology in dairy cows with clinical endometritis. Journ Vet Med Sci 78 (4), 551-556 PubMed
  • Borucki Castro S I et al (2012) Effects of iodine intake and teat-dipping practices on milk iodine concentrations in dairy cows. J Dairy Sci 95 (1), 213-220 PubMed.
  • Paulikova G et al (2002) Iodine toxicity in ruminants. Vet Med – Czech 47 (12), 343-350 www.researchgate.net (pdf online). 
  • Desrochers A et al (1996) Comparative evaluation of two surgical scrub preparations in cattle. Vet Surg 25 (4), 336-341 PubMed.

Other sources of information

  • Based on Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.
  • Committee for veterinary medicinal products. Iodine summary Report. European Agency for the Evaluation of Medicinal Products. Website: www.ema.europa.eu.
  • The NOAH Compendium. Datasheets of Licensed Veterinary Medicines. Website: www.noahcompendium.co.uk.
  • US Food & Drug Administration (FDA). Questions and Answers on FDA's Adverse Event Reporting System (FAERS). Website: www.fda.gov.
  • Veterinary Medicines Directorate. Adverse Reaction Reporting. Website: www.vmd.defra.gov.uk.

Organisation(s)

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