ISSN 2398-2993      

Clorsulon

obovis
Contributor(s):

Rob Kelly

Andrew Forbes

Royal Dick School Veterinary Studies logo


Introduction

Name

  • Clorsulon.

Class of drug

  • Benzenesulfonamide.

Description

Chemical name

  • 4-amino-6-(trichlorovinyl)-m-benzenedisulfonamide.

Molecular formula

  • C8H8Cl3N3O4S2.

Molecular weight

  • 380.66.

Physical properties

  • Fluid formulation usually of clear colorless to pale yellow color.
  • Powder formulations, which are not licensed for use in animals, are available usually white in color with a melting point of ~200oC/392oF.

Storage requirements

Uses

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Indications

  • Treatment and control of adult Fasciola spp infections in cattle.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • None reported.

With diagnostic tests

  • None reported.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Fairweather I, Brennan G P, Hanna R E B, Robinson M W & Skuce P J (2020) Drug resistance in liver flukes. Int J Parasitol Drugs Drug Resist 12, 39-59 PubMed. doi:10.1016/j.ijpddr.2019.11.003.
  • Howell A K & Williams D J L (2020) The epidemiology and control of liver flukes in cattle and sheep. Vet Clin North Am Food Anim Pract 36 (1), 109-123 PubMed. doi:10.1016/j.cvfa.2019.12.002.
  • Forbes A B, Reddick D & Stear M J (2014) Efficacy of treatment of cattle for liver fluke at housing: influence of differences in flukicidal activity against juvenile Fasciola hepatica. Vet Rec 176 (13), 333-345 PubMed. doi:10.1136/vr.102720.
  • Hutchinson G W, Dawson K, Fitzgibbon C C & Martin P J (2009) Efficacy of an injectable combination anthelmintic (nitroxynil + clorsulon + ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle. Vet Parasitol 162 (3-4), 278-284 PubMed. doi:10.1016/j.vetpar.2009.03.032.
  • Meaney M, Fairweather I, Brennan G P, McDowell L S L & Forbes A B (2003) Fasciola hepatica: effects of the fasciolicide clorsulon in vitro and in vivo on the tegumental surface, and a comparison of the effects on young- and old-mature flukes. Parasitol Res 91 (3), 238-250 PubMed. doi:10.1007/s00436-003-0863-0.
  • Loyacano A F, Williams J C, Gurie J & DeRosa A A (2002) Effect of gastrointestinal nematode and liver fluke infections on weight gain and reproductive performance of beef heifers. Vet Parasitol 107 (3), 227-234 PubMed. doi:10.1016/S0304-4017(02)00130-9.
  • Mitchell G (2002) Update on fasciolosis in cattle and sheep. In Pract 24 (7), 378-385 VetMedResource. doi:10.1136/inpract.24.7.378.
  • Coles G C & Stafford K A (2001) Activity of oxyclozanide, nitroxynil, clorsulon and albendazole against adult triclabendazole-resistant Fasciola hepatica. Vet Rec 148 (23), 723-724 VetMedResource. doi:10.1136/vr.148.23.723.
  • Fairweather I & Boray J C (1999) Fasciolicides: efficacy, actions, resistance and its management. Vet J 158 (2), 81-112 PubMed. doi:10.1053/tvjl.1999.0377.
  • Martin R J (1997) Modes of action of anthelmintic drugs. Vet J 154 (1), 11-34. doi:10.1016/S1090-0233(05)80005-X.
  • Rickard L G, Zimmerman G L, Hoberg E P & Bishop J K, Pettitt R J (1992) Influence of ivermectin and clorsulon treatment on productivity of a cow-calf herd on the southern Oregon coast. Vet Parasitol 41 (1-2), 45-55 PubMed. doi:10.1016/0304-4017(92)90007-V.

Other sources of information

  • Deplazes P, Eckert J, Mathias A, von Samson-Himmelstjerna & Zahner H (2016) Helminths and Principles of Therapy and Control. In: Parasitology in Veterinary Medicine. Wageningen Academic Publishers. pp 175-186, 191-197, 224-254, 287-302, 303-312, 556-572.
  • Taylor M A, Coop R L & Wall R L (2007) Veterinary Helminthology from Cattle, Sheep and Resistance Sections. In: Veterinary Parasitology. 3rd edn. Blackwell Science. pp 51-91, 152-212, 770-775.
  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Available at: www.noahcompendium.co.uk.
  • The NOAH Compendium. Datasheets of licensed veterinary medicines. Available at: https://www.noahcompendium.co.uk.
  • Veterinary Medicines Directorate. Adverse Reaction Reporting. Available at: https://www.vmd.defra.gov.uk.
  • Veterinary Medicines Directorate. Questions and Answers on FDA's Adverse Event Reporting System (FAERS). Available at:  https://www.noahcompendium.co.uk/home.
  • Veterinary Substances Database. Website: http://sitem.herts.ac.uk. Accessed October 23, 2020.

Organisation(s)

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