ISSN 2398-2993      

Biotin

obovis
Contributor(s):

Eilidh Thomson

Nick Bell

Synonym(s): Vitamin H


Introduction

Name

  • Biotin (vitamin B7).
  • Also known informally as vitamin H.

Class of drug

  • B-complex vitamin.

Description

Chemical name

  • 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid.

Molecular formula

  • C10H16N2O3S.

Molecular weight

  • 244.31 g/mol.

Physical properties

  • Boiling point: 573.6°C/1064.48°F.
  • Melting point: 232°C/449.6°F.
  • Water soluble.

Storage requirements

  • Cool and dry.

Uses

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Indications

  • Biotin supplementation has been indicated as helpful in reducing lameness caused by white line disease White line disease.
  • There is evidence that supplementation with biotin can increase milk production.

Administration

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Pharmacokinetics

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Saint Paul L P, Debruyne D, Bernard D et al (2016) Pharmacokinetics and Pharmacodynamics of MD1003 (high dose biotin) in the treatment of progressive multiple sclerosis. Expert Opin on Drug Metab Toxicol 12 (3), 327-344 PubMed.
  • Chen B, Wang C, Wang Y M & Liu J X (2011) Effect of biotin on milk performance of dairy cattle: a meta-analysis. J Dairy Sci 94 (7), 3537–3546 PubMed.
  • Lean I J & Rabiee A R (2011) Effect of feeding biotin on milk production and hoof health in lactating dairy cows: A quantitative assessment. J Dairy Sci 94 (3), 1465-1476 PubMed.
  • Ferreira G, Weiss W P & Willett L B (2007) Changes in measures of biotin status do not reflect milk yield responses when dairy cows are fed supplemental biotin. J Dairy Sci 90 (3), 1452-1459 PubMed.
  • Zimmerly C A & Weiss W P (2001) Effects of supplemental dietary Biotin on performance of Holstein cows during early lactation. J Dairy Sci 84 (2), 498-506 PubMed.
  • Hedges J, Blowey R W et al (2001) A longitudinal field trial of biotin on lameness in dairy cows. J Dairy Sci 84 (9), 1969-1975 PubMed.

Other sources of information

  • Lennarz W J (2013) Encyclopedia of Biological Chemistry. 2nd edn. Ed: Lane M D. Academic Press, UK.
  • Boden E (2005) Ed. Black’s Veterinary Dictionary. 21st edn. A & C Black, UK.
  • Veterinary Medicines Directorate. Adverse Reaction Reporting. Website: www.vmd.defra.gov.uk.
  • Veterinary Medicines Directorate. Questions and Answers on FDA's Adverse Event Reporting System (FAERS). Website: www.noahcompendium.co.uk.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
  • Veterinary Medicines Directorate (VMD) Product Information Database. Website: www.vmd.defra.gov.uk.
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